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Aminoglycosides are antibiotics which act by inhibiting protein synthesis. They act by binding to 30S ribosomal subunit and cause misreading of the genetic code. The term ‘Aminoglycoside’ represents their structure which is two amino sugars joined by a glcosidic linkage to a central hexose nucleus.
Examples: Amikacin, Gentamicin, Neomycin, Streptomycin, Tobramycin etc.
The suffix micin and mycin are added according to the species from which they have been derived. The aminoglycoside derived from Streptomyces species, the suffix mycin is added and the aminoglycoside derived from Micromonospora species, the suffix micin is added.
References:
- Goodman and Gilman’s The Pharmacological Basis of Therapeutics, 14th Edition
- Lippincott Illustrated Reviews: Pharmacology 7th Edition
